Molecular Evolution of Human Coronavirus Genomes
Identifieur interne : 001809 ( Ncbi/Merge ); précédent : 001808; suivant : 001810Molecular Evolution of Human Coronavirus Genomes
Auteurs : Diego Forni [Italie] ; Rachele Cagliani [Italie] ; Mario Clerici [Italie] ; Manuela Sironi [Italie]Source :
- Trends in Microbiology [ 0966-842X ] ; 2016.
Descripteurs français
- KwdFr :
- Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Génome viral (génétique), Humains, Hémagglutinines virales (génétique), Hémagglutinines virales (métabolisme), Phosphodiesterases (génétique), Phosphodiesterases (métabolisme), Protéines de fusion virale (génétique), Protéines de fusion virale (métabolisme), Protéines virales régulatrices ou accessoires (génétique), Protéines virales régulatrices ou accessoires (métabolisme), Spécificité d'hôte (génétique), Virus du SRAS (génétique), Évolution moléculaire.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Génome viral, Hémagglutinines virales, Phosphodiesterases, Protéines de fusion virale, Protéines virales régulatrices ou accessoires, Spécificité d'hôte, Virus du SRAS.
- métabolisme : Hémagglutinines virales, Phosphodiesterases, Protéines de fusion virale, Protéines virales régulatrices ou accessoires.
- Humains, Évolution moléculaire.
English descriptors
- KwdEn :
- Evolution, Molecular, Genome, Viral (genetics), Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (metabolism), Host Specificity (genetics), Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Phosphoric Diester Hydrolases (genetics), Phosphoric Diester Hydrolases (metabolism), SARS Virus (genetics), Viral Fusion Proteins (genetics), Viral Fusion Proteins (metabolism), Viral Regulatory and Accessory Proteins (genetics), Viral Regulatory and Accessory Proteins (metabolism).
- MESH :
- chemical , genetics : Hemagglutinins, Viral, Phosphoric Diester Hydrolases, Viral Fusion Proteins, Viral Regulatory and Accessory Proteins.
- genetics : Genome, Viral, Host Specificity, Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- chemical , metabolism : Hemagglutinins, Viral, Phosphoric Diester Hydrolases, Viral Fusion Proteins, Viral Regulatory and Accessory Proteins.
- Evolution, Molecular, Humans.
Abstract
Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence.
Url:
DOI: 10.1016/j.tim.2016.09.001
PubMed: 27743750
PubMed Central: 7111218
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001422
- to stream Pmc, to step Curation: 001422
- to stream Pmc, to step Checkpoint: 000A64
- to stream PubMed, to step Corpus: 000F32
- to stream PubMed, to step Curation: 000F32
- to stream PubMed, to step Checkpoint: 000C03
Links to Exploration step
PMC:7111218Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Evolution of Human Coronavirus Genomes</title><author><name sortKey="Forni, Diego" sort="Forni, Diego" uniqKey="Forni D" first="Diego" last="Forni">Diego Forni</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Cagliani, Rachele" sort="Cagliani, Rachele" uniqKey="Cagliani R" first="Rachele" last="Cagliani">Rachele Cagliani</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Clerici, Mario" sort="Clerici, Mario" uniqKey="Clerici M" first="Mario" last="Clerici">Mario Clerici</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Physiopathology and Transplantation, University of Milan, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiopathology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Don C. Gnocchi Foundation ONLUS, IRCCS, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sironi, Manuela" sort="Sironi, Manuela" uniqKey="Sironi M" first="Manuela" last="Sironi">Manuela Sironi</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27743750</idno><idno type="pmc">7111218</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111218</idno><idno type="RBID">PMC:7111218</idno><idno type="doi">10.1016/j.tim.2016.09.001</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001422</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001422</idno><idno type="wicri:Area/Pmc/Curation">001422</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001422</idno><idno type="wicri:Area/Pmc/Checkpoint">000A64</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A64</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:27743750</idno><idno type="wicri:Area/PubMed/Corpus">000F32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F32</idno><idno type="wicri:Area/PubMed/Curation">000F32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F32</idno><idno type="wicri:Area/PubMed/Checkpoint">000C03</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C03</idno><idno type="wicri:Area/Ncbi/Merge">001809</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Evolution of Human Coronavirus Genomes</title><author><name sortKey="Forni, Diego" sort="Forni, Diego" uniqKey="Forni D" first="Diego" last="Forni">Diego Forni</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Cagliani, Rachele" sort="Cagliani, Rachele" uniqKey="Cagliani R" first="Rachele" last="Cagliani">Rachele Cagliani</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Clerici, Mario" sort="Clerici, Mario" uniqKey="Clerici M" first="Mario" last="Clerici">Mario Clerici</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Physiopathology and Transplantation, University of Milan, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiopathology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Don C. Gnocchi Foundation ONLUS, IRCCS, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sironi, Manuela" sort="Sironi, Manuela" uniqKey="Sironi M" first="Manuela" last="Sironi">Manuela Sironi</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author></analytic><series><title level="j">Trends in Microbiology</title><idno type="ISSN">0966-842X</idno><idno type="eISSN">1878-4380</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Evolution, Molecular</term><term>Genome, Viral (genetics)</term><term>Hemagglutinins, Viral (genetics)</term><term>Hemagglutinins, Viral (metabolism)</term><term>Host Specificity (genetics)</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Phosphoric Diester Hydrolases (genetics)</term><term>Phosphoric Diester Hydrolases (metabolism)</term><term>SARS Virus (genetics)</term><term>Viral Fusion Proteins (genetics)</term><term>Viral Fusion Proteins (metabolism)</term><term>Viral Regulatory and Accessory Proteins (genetics)</term><term>Viral Regulatory and Accessory Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Génome viral (génétique)</term><term>Humains</term><term>Hémagglutinines virales (génétique)</term><term>Hémagglutinines virales (métabolisme)</term><term>Phosphodiesterases (génétique)</term><term>Phosphodiesterases (métabolisme)</term><term>Protéines de fusion virale (génétique)</term><term>Protéines de fusion virale (métabolisme)</term><term>Protéines virales régulatrices ou accessoires (génétique)</term><term>Protéines virales régulatrices ou accessoires (métabolisme)</term><term>Spécificité d'hôte (génétique)</term><term>Virus du SRAS (génétique)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Phosphoric Diester Hydrolases</term><term>Viral Fusion Proteins</term><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genome, Viral</term><term>Host Specificity</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Génome viral</term><term>Hémagglutinines virales</term><term>Phosphodiesterases</term><term>Protéines de fusion virale</term><term>Protéines virales régulatrices ou accessoires</term><term>Spécificité d'hôte</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Phosphoric Diester Hydrolases</term><term>Viral Fusion Proteins</term><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Hémagglutinines virales</term><term>Phosphodiesterases</term><term>Protéines de fusion virale</term><term>Protéines virales régulatrices ou accessoires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Evolution, Molecular</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><p>Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence.</p></sec><sec><title>Video Abstract</title><p><supplementary-material content-type="local-data" id="mmc1"><media xlink:href="mmc1.flv"></media></supplementary-material></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drexler, J F" uniqKey="Drexler J">J.F. Drexler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S. Su</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckerle, L D" uniqKey="Eckerle L">L.D. Eckerle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckerle, L D" uniqKey="Eckerle L">L.D. Eckerle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vega, V B" uniqKey="Vega V">V.B. Vega</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lauber, C" uniqKey="Lauber C">C. Lauber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subissi, L" uniqKey="Subissi L">L. Subissi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, V D" uniqKey="Menachery V">V.D. Menachery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, X Y" uniqKey="Ge X">X.Y. Ge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X L" uniqKey="Yang X">X.L. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z. Wu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Scheffler, K" uniqKey="Scheffler K">K. Scheffler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wertheim, J O" uniqKey="Wertheim J">J.O. Wertheim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crossley, B M" uniqKey="Crossley B">B.M. Crossley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crossley, B M" uniqKey="Crossley B">B.M. Crossley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sabir, J S" uniqKey="Sabir J">J.S. Sabir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gusho, E" uniqKey="Gusho E">E. Gusho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thornbrough, J M" uniqKey="Thornbrough J">J.M. Thornbrough</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, G" uniqKey="Peng G">G. Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, X" uniqKey="Huang X">X. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desforges, M" uniqKey="Desforges M">M. Desforges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R. Dijkman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farsani, S M" uniqKey="Farsani S">S.M. Farsani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, W" uniqKey="Lu W">W. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koetzner, C A" uniqKey="Koetzner C">C.A. Koetzner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, G P" uniqKey="Zhao G">G.P. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, J I" uniqKey="Kim J">J.I. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forni, D" uniqKey="Forni D">D. Forni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M. Cotten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamada, Y" uniqKey="Yamada Y">Y. Yamada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S. Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcroy, W C" uniqKey="Mcroy W">W.C. McRoy</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forni, D" uniqKey="Forni D">D. Forni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rasschaert, D" uniqKey="Rasschaert D">D. Rasschaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez, C M" uniqKey="Sanchez C">C.M. Sanchez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K. Pyrc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, K" uniqKey="Wu K">K. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reguera, J" uniqKey="Reguera J">J. Reguera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milewska, A" uniqKey="Milewska A">A. Milewska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, C A" uniqKey="De Haan C">C.A. de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Khannaq, M N" uniqKey="Al Khannaq M">M.N. Al-Khannaq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, L" uniqKey="Ren L">L. Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, Z" uniqKey="Qian Z">Z. Qian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirchdoerfer, R N" uniqKey="Kirchdoerfer R">R.N. Kirchdoerfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dominguez, S R" uniqKey="Dominguez S">S.R. Dominguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pickett, B E" uniqKey="Pickett B">B.E. Pickett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anisimova, M" uniqKey="Anisimova M">M. Anisimova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guindon, S" uniqKey="Guindon S">S. Guindon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stamatakis, A" uniqKey="Stamatakis A">A. Stamatakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ronquist, F" uniqKey="Ronquist F">F. Ronquist</name></author><author><name sortKey="Huelsenbeck, J P" uniqKey="Huelsenbeck J">J.P. Huelsenbeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosakovsky Pond, S L" uniqKey="Kosakovsky Pond S">S.L. Kosakovsky Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maydt, J" uniqKey="Maydt J">J. Maydt</name></author><author><name sortKey="Lengauer, T" uniqKey="Lengauer T">T. Lengauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, D" uniqKey="Martin D">D. Martin</name></author><author><name sortKey="Rybicki, E" uniqKey="Rybicki E">E. Rybicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murrell, B" uniqKey="Murrell B">B. Murrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosakovsky Pond, S L" uniqKey="Kosakovsky Pond S">S.L. Kosakovsky Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcdonald, J H" uniqKey="Mcdonald J">J.H. McDonald</name></author><author><name sortKey="Kreitman, M" uniqKey="Kreitman M">M. Kreitman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gharib, W H" uniqKey="Gharib W">W.H. Gharib</name></author><author><name sortKey="Robinson Rechavi, M" uniqKey="Robinson Rechavi M">M. Robinson-Rechavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xia, X" uniqKey="Xia X">X. Xia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sealfon, R S" uniqKey="Sealfon R">R.S. Sealfon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, R J" uniqKey="De Groot R">R.J. de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wertheim, J O" uniqKey="Wertheim J">J.O. Wertheim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blair, J E" uniqKey="Blair J">J.E. Blair</name></author><author><name sortKey="Hedges, S B" uniqKey="Hedges S">S.B. Hedges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huynh, J" uniqKey="Huynh J">J. Huynh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfefferle, S" uniqKey="Pfefferle S">S. Pfefferle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijgen, L" uniqKey="Vijgen L">L. Vijgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gralinski, L E" uniqKey="Gralinski L">L.E. Gralinski</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krogh, A" uniqKey="Krogh A">A. Krogh</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="27743750"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Evolution of Human Coronavirus Genomes</title><author><name sortKey="Forni, Diego" sort="Forni, Diego" uniqKey="Forni D" first="Diego" last="Forni">Diego Forni</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Cagliani, Rachele" sort="Cagliani, Rachele" uniqKey="Cagliani R" first="Rachele" last="Cagliani">Rachele Cagliani</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Clerici, Mario" sort="Clerici, Mario" uniqKey="Clerici M" first="Mario" last="Clerici">Mario Clerici</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Physiopathology and Transplantation, University of Milan, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiopathology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Don C. Gnocchi Foundation ONLUS, IRCCS, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sironi, Manuela" sort="Sironi, Manuela" uniqKey="Sironi M" first="Manuela" last="Sironi">Manuela Sironi</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27743750</idno><idno type="pmc">7111218</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111218</idno><idno type="RBID">PMC:7111218</idno><idno type="doi">10.1016/j.tim.2016.09.001</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001422</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001422</idno><idno type="wicri:Area/Pmc/Curation">001422</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001422</idno><idno type="wicri:Area/Pmc/Checkpoint">000A64</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Evolution of Human Coronavirus Genomes</title><author><name sortKey="Forni, Diego" sort="Forni, Diego" uniqKey="Forni D" first="Diego" last="Forni">Diego Forni</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Cagliani, Rachele" sort="Cagliani, Rachele" uniqKey="Cagliani R" first="Rachele" last="Cagliani">Rachele Cagliani</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Clerici, Mario" sort="Clerici, Mario" uniqKey="Clerici M" first="Mario" last="Clerici">Mario Clerici</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Department of Physiopathology and Transplantation, University of Milan, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiopathology and Transplantation, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff0015">Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Don C. Gnocchi Foundation ONLUS, IRCCS, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sironi, Manuela" sort="Sironi, Manuela" uniqKey="Sironi M" first="Manuela" last="Sironi">Manuela Sironi</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author></analytic><series><title level="j">Trends in Microbiology</title><idno type="ISSN">0966-842X</idno><idno type="eISSN">1878-4380</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><p>Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence.</p></sec><sec><title>Video Abstract</title><p><supplementary-material content-type="local-data" id="mmc1"><media xlink:href="mmc1.flv"></media></supplementary-material></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drexler, J F" uniqKey="Drexler J">J.F. Drexler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S. Su</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckerle, L D" uniqKey="Eckerle L">L.D. Eckerle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckerle, L D" uniqKey="Eckerle L">L.D. Eckerle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vega, V B" uniqKey="Vega V">V.B. Vega</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lauber, C" uniqKey="Lauber C">C. Lauber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subissi, L" uniqKey="Subissi L">L. Subissi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, V D" uniqKey="Menachery V">V.D. Menachery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, X Y" uniqKey="Ge X">X.Y. Ge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X L" uniqKey="Yang X">X.L. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Z" uniqKey="Wu Z">Z. Wu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Scheffler, K" uniqKey="Scheffler K">K. Scheffler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wertheim, J O" uniqKey="Wertheim J">J.O. Wertheim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crossley, B M" uniqKey="Crossley B">B.M. Crossley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crossley, B M" uniqKey="Crossley B">B.M. Crossley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sabir, J S" uniqKey="Sabir J">J.S. Sabir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gusho, E" uniqKey="Gusho E">E. Gusho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thornbrough, J M" uniqKey="Thornbrough J">J.M. Thornbrough</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author><author><name sortKey="Li, F" uniqKey="Li F">F. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, G" uniqKey="Peng G">G. Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, X" uniqKey="Huang X">X. Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desforges, M" uniqKey="Desforges M">M. Desforges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R. Dijkman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farsani, S M" uniqKey="Farsani S">S.M. Farsani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, W" uniqKey="Lu W">W. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koetzner, C A" uniqKey="Koetzner C">C.A. Koetzner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, G P" uniqKey="Zhao G">G.P. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, R L" uniqKey="Graham R">R.L. Graham</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, G" uniqKey="Lu G">G. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, V M" uniqKey="Corman V">V.M. Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, J I" uniqKey="Kim J">J.I. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forni, D" uniqKey="Forni D">D. Forni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M. Cotten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamada, Y" uniqKey="Yamada Y">Y. Yamada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navas Martin, S" uniqKey="Navas Martin S">S. Navas-Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcroy, W C" uniqKey="Mcroy W">W.C. McRoy</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forni, D" uniqKey="Forni D">D. Forni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baez Santos, Y M" uniqKey="Baez Santos Y">Y.M. Baez-Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rasschaert, D" uniqKey="Rasschaert D">D. Rasschaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez, C M" uniqKey="Sanchez C">C.M. Sanchez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K. Pyrc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, K" uniqKey="Wu K">K. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reguera, J" uniqKey="Reguera J">J. Reguera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Milewska, A" uniqKey="Milewska A">A. Milewska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, C A" uniqKey="De Haan C">C.A. de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Khannaq, M N" uniqKey="Al Khannaq M">M.N. Al-Khannaq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, L" uniqKey="Ren L">L. Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, Z" uniqKey="Qian Z">Z. Qian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirchdoerfer, R N" uniqKey="Kirchdoerfer R">R.N. Kirchdoerfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dominguez, S R" uniqKey="Dominguez S">S.R. Dominguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pickett, B E" uniqKey="Pickett B">B.E. Pickett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anisimova, M" uniqKey="Anisimova M">M. Anisimova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guindon, S" uniqKey="Guindon S">S. Guindon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stamatakis, A" uniqKey="Stamatakis A">A. Stamatakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ronquist, F" uniqKey="Ronquist F">F. Ronquist</name></author><author><name sortKey="Huelsenbeck, J P" uniqKey="Huelsenbeck J">J.P. Huelsenbeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosakovsky Pond, S L" uniqKey="Kosakovsky Pond S">S.L. Kosakovsky Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maydt, J" uniqKey="Maydt J">J. Maydt</name></author><author><name sortKey="Lengauer, T" uniqKey="Lengauer T">T. Lengauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, D" uniqKey="Martin D">D. Martin</name></author><author><name sortKey="Rybicki, E" uniqKey="Rybicki E">E. Rybicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murrell, B" uniqKey="Murrell B">B. Murrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosakovsky Pond, S L" uniqKey="Kosakovsky Pond S">S.L. Kosakovsky Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcdonald, J H" uniqKey="Mcdonald J">J.H. McDonald</name></author><author><name sortKey="Kreitman, M" uniqKey="Kreitman M">M. Kreitman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gharib, W H" uniqKey="Gharib W">W.H. Gharib</name></author><author><name sortKey="Robinson Rechavi, M" uniqKey="Robinson Rechavi M">M. Robinson-Rechavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xia, X" uniqKey="Xia X">X. Xia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sealfon, R S" uniqKey="Sealfon R">R.S. Sealfon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, R J" uniqKey="De Groot R">R.J. de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wertheim, J O" uniqKey="Wertheim J">J.O. Wertheim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blair, J E" uniqKey="Blair J">J.E. Blair</name></author><author><name sortKey="Hedges, S B" uniqKey="Hedges S">S.B. Hedges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huynh, J" uniqKey="Huynh J">J. Huynh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfefferle, S" uniqKey="Pfefferle S">S. Pfefferle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijgen, L" uniqKey="Vijgen L">L. Vijgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gralinski, L E" uniqKey="Gralinski L">L.E. Gralinski</name></author><author><name sortKey="Baric, R S" uniqKey="Baric R">R.S. Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krogh, A" uniqKey="Krogh A">A. Krogh</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Evolution of Human Coronavirus Genomes.</title><author><name sortKey="Forni, Diego" sort="Forni, Diego" uniqKey="Forni D" first="Diego" last="Forni">Diego Forni</name><affiliation wicri:level="1"><nlm:affiliation>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Cagliani, Rachele" sort="Cagliani, Rachele" uniqKey="Cagliani R" first="Rachele" last="Cagliani">Rachele Cagliani</name><affiliation wicri:level="1"><nlm:affiliation>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Clerici, Mario" sort="Clerici, Mario" uniqKey="Clerici M" first="Mario" last="Clerici">Mario Clerici</name><affiliation wicri:level="3"><nlm:affiliation>Department of Physiopathology and Transplantation, University of Milan, Milan, Italy; Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiopathology and Transplantation, University of Milan, Milan, Italy; Don C. Gnocchi Foundation ONLUS, IRCCS, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sironi, Manuela" sort="Sironi, Manuela" uniqKey="Sironi M" first="Manuela" last="Sironi">Manuela Sironi</name><affiliation wicri:level="1"><nlm:affiliation>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy. Electronic address: manuela.sironi@bp.lnf.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27743750</idno><idno type="pmid">27743750</idno><idno type="doi">10.1016/j.tim.2016.09.001</idno><idno type="wicri:Area/PubMed/Corpus">000F32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F32</idno><idno type="wicri:Area/PubMed/Curation">000F32</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F32</idno><idno type="wicri:Area/PubMed/Checkpoint">000C03</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular Evolution of Human Coronavirus Genomes.</title><author><name sortKey="Forni, Diego" sort="Forni, Diego" uniqKey="Forni D" first="Diego" last="Forni">Diego Forni</name><affiliation wicri:level="1"><nlm:affiliation>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Cagliani, Rachele" sort="Cagliani, Rachele" uniqKey="Cagliani R" first="Rachele" last="Cagliani">Rachele Cagliani</name><affiliation wicri:level="1"><nlm:affiliation>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author><author><name sortKey="Clerici, Mario" sort="Clerici, Mario" uniqKey="Clerici M" first="Mario" last="Clerici">Mario Clerici</name><affiliation wicri:level="3"><nlm:affiliation>Department of Physiopathology and Transplantation, University of Milan, Milan, Italy; Don C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Physiopathology and Transplantation, University of Milan, Milan, Italy; Don C. Gnocchi Foundation ONLUS, IRCCS, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sironi, Manuela" sort="Sironi, Manuela" uniqKey="Sironi M" first="Manuela" last="Sironi">Manuela Sironi</name><affiliation wicri:level="1"><nlm:affiliation>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini, Italy. Electronic address: manuela.sironi@bp.lnf.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Scientific Institute IRCCS E. MEDEA, Bioinformatics, Bosisio Parini</wicri:regionArea><wicri:noRegion>Bosisio Parini</wicri:noRegion></affiliation></author></analytic><series><title level="j">Trends in microbiology</title><idno type="eISSN">1878-4380</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Evolution, Molecular</term><term>Genome, Viral (genetics)</term><term>Hemagglutinins, Viral (genetics)</term><term>Hemagglutinins, Viral (metabolism)</term><term>Host Specificity (genetics)</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Phosphoric Diester Hydrolases (genetics)</term><term>Phosphoric Diester Hydrolases (metabolism)</term><term>SARS Virus (genetics)</term><term>Viral Fusion Proteins (genetics)</term><term>Viral Fusion Proteins (metabolism)</term><term>Viral Regulatory and Accessory Proteins (genetics)</term><term>Viral Regulatory and Accessory Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Génome viral (génétique)</term><term>Humains</term><term>Hémagglutinines virales (génétique)</term><term>Hémagglutinines virales (métabolisme)</term><term>Phosphodiesterases (génétique)</term><term>Phosphodiesterases (métabolisme)</term><term>Protéines de fusion virale (génétique)</term><term>Protéines de fusion virale (métabolisme)</term><term>Protéines virales régulatrices ou accessoires (génétique)</term><term>Protéines virales régulatrices ou accessoires (métabolisme)</term><term>Spécificité d'hôte (génétique)</term><term>Virus du SRAS (génétique)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Phosphoric Diester Hydrolases</term><term>Viral Fusion Proteins</term><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genome, Viral</term><term>Host Specificity</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Génome viral</term><term>Hémagglutinines virales</term><term>Phosphodiesterases</term><term>Protéines de fusion virale</term><term>Protéines virales régulatrices ou accessoires</term><term>Spécificité d'hôte</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Phosphoric Diester Hydrolases</term><term>Viral Fusion Proteins</term><term>Viral Regulatory and Accessory Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Hémagglutinines virales</term><term>Phosphodiesterases</term><term>Protéines de fusion virale</term><term>Protéines virales régulatrices ou accessoires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Evolution, Molecular</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human coronaviruses (HCoVs), including SARS-CoV and MERS-CoV, are zoonotic pathogens that originated in wild animals. HCoVs have large genomes that encode a fixed array of structural and nonstructural components, as well as a variety of accessory proteins that differ in number and sequence even among closely related CoVs. Thus, in addition to recombination and mutation, HCoV genomes evolve through gene gains and losses. In this review we summarize recent findings on the molecular evolution of HCoV genomes, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to HCoV emergence. VIDEO ABSTRACT.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001809 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001809 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:7111218
|texte= Molecular Evolution of Human Coronavirus Genomes
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:27743750" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |